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CORE

The database for complement-mediated diseases and TMAs

About CORE

Information for Patients

You can take part in the CORE registry if you have been diagnosed with one of the following conditions:

  • thrombotic thrombocytopenic purpura (TTP)

  • atypical haemolytic uraemic syndrome (aHUS)

  • C3 glomerulopathy

    • This includes the entities C3 glomerulonephritis and dense deposit disease

  • immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN)

Information for Physicians

As a physician, would you like to enrol a patient with a complement-mediated kidney disease or a TMA in the CORE registry?

About the Study

Background

Thrombotic microangiopathies (TMAs) and complement-mediated kidney diseases are rare but serious conditions. They are associated with damage to the small blood vessels and a dysregulation of the complement system (an important part of the immune system).

News

CORE registry is now live

The registry for complement-mediated diseases and TMAs is open to participating centres starting today.

on May 15, 2026

CORE registry is now live

Study coordination centre opens in Cologne

In January, the central office of the CORE registry at University Hospital Cologne officially begins its work.

on Jan 18, 2026

Study coordination centre opens in Cologne

First data release for researchers

For the first time, the CORE registry is making anonymised follow-up data available for external research projects.

on Dec 12, 2025

First data release for researchers

Scientific advisory board constituted

The scientific advisory board of the CORE registry comprises seven internationally recognised members and has begun its work.

on Nov 20, 2025

Scientific advisory board constituted

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